Roger Federer is into the third round of the Paris Masters after Milos Raonic withdrew with an elbow injury.

It means the Swiss 20-time Grand Slam champion, who had a first-round bye, has made the last 16 without playing.

Earlier, Kei Nishikori had a straightforward 7-5 6-4 victory over Adrian Mannarino and John Isner served up 33 aces as he beat Mikhail Kukushkin 6-3 6-7 (2-7) 7-6 (7-1).

Rafael Nadal faces Fernando Verdasco later on Wednesday.

Japan’s Nishikori, 28, did not face a single break point as he defeated home crowd favourite Mannarino in one hour and 27 minutes to progress.

The 10th seed crucially broke the Frenchman at 5-5 in the first set and 3-3 in the second to set up the win.

He will meet seventh seed Kevin Anderson or Georgian Nikoloz Basilashvili in the next round.

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On Court One, John Isner beat Kazakh Mikhail Kukushkin 6-3 6-7 (2-7) 7-6 (7-1).

Isner’s powerful serving ensured he was not broken all match – hitting 33 aces – but wasted opportunities saw him struggle to break Kukushkin as the game wore on.

The American’s serve only let him down at the second set tie-break, as the world number 54 forced a deciding set.

That went the distance too but this was a different story for Isner, who won early points against the Kazakh’s serve to take the match.

Isner needs to reach the semi-finals in Paris to have any hope of moving up to ninth in the rankings, which would give him a chance of making the season-ending ATP Finals in London in November.

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Later on Wednesday, Alexander Zverev beat Frenchman Frances Tiafoe 6-4 6-4.

The pair traded missed break points in first set before the German, 21, won the final game on Tiafoe’s serve.

In the second set, Zverev broke three times but was broken twice as he wrapped up the eventful match in one hour and 44 minutes.

Ninth seed Grigor Dimitrov is also through after beating Roberto Bautista Agut 7-6 (12-10) 6-4.